Affiliation:
1. Department of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, United Kingdom
Abstract
ABSTRACT
Antibiotic-resistant
Enterococcus faecalis
and
Clostridium difficile
are responsible for nosocomial infections in humans, in which they inhabit the same niche. Here, we demonstrate transfer of the conjugative transposon Tn
5397
from
C. difficile
630 to
E. faecalis
JH2-2, the first reported gene transfer between these two bacteria. Furthermore, transfer from the
E. faecalis
EF20A transconjugant to the epidemic ribotype 027
C. difficile
strain R20291 was also demonstrated. Tn
5397
was shown to use a single specific target site in
E. faecalis
; it also has specific target sites in
C. difficile
. These experiments highlight the importance of continual monitoring for emerging resistances in these bacteria.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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