Low-Level Rifampin Resistance and rpoB Mutations in Mycobacterium tuberculosis: an Analysis of Whole-Genome Sequencing and Drug Susceptibility Test Data in New York-Reference-Cited by-同舟云学术

Low-Level Rifampin Resistance and rpoB Mutations in Mycobacterium tuberculosis: an Analysis of Whole-Genome Sequencing and Drug Susceptibility Test Data in New York

Published:2021-03-19 Issue:4 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Shea Joseph¹,Halse Tanya A.¹,Kohlerschmidt Donna¹,Lapierre Pascal¹^ORCID,Modestil Herns A.²,Kearns Cheryl H.³,Dworkin Felicia F.²,Rakeman Jennifer L.⁴^ORCID,Escuyer Vincent¹,Musser Kimberlee A.¹^ORCID

Affiliation:

1. Wadsworth Center, New York State Department of Health, Albany, New York, USA

2. New York City Department of Health and Mental Hygiene, New York, New York, USA

3. New York State Department of Health, Albany, New York, USA

4. Public Health Laboratory, New York City Department of Health and Mental Hygiene, New York, New York, USA

Abstract

Rapid and reliable detection of rifampin (RIF) resistance is critical for the diagnosis and treatment of drug-resistant and multidrug-resistant (MDR) tuberculosis. Discordant RIF phenotype/genotype susceptibility results remain a challenge due to the presence of rpoB mutations that do not confer high levels of RIF resistance, as have been exhibited in strains with mutations such as Ser450Leu.

Funder

Association of Public Health Laboratories

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01885-20

Reference75 articles.

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2. Mapping and sequencing of mutations in the Escherichia colirpoB gene that lead to rifampicin resistance

3. Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis