Structure-Aware Mycobacterium tuberculosis Functional Annotation Uncloaks Resistance, Metabolic, and Virulence Genes-Reference-Cited by-同舟云学术

Structure-Aware Mycobacterium tuberculosis Functional Annotation Uncloaks Resistance, Metabolic, and Virulence Genes

Published:2021-12-21 Issue:6 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Modlin Samuel J.¹^ORCID,Elghraoui Afif¹^ORCID,Gunasekaran Deepika¹,Zlotnicki Alyssa M.¹,Dillon Nicholas A.²^ORCID,Dhillon Nermeeta¹,Kuo Norman¹,Robinhold Cassidy¹,Chan Carmela K.¹,Baughn Anthony D.²^ORCID,Valafar Faramarz¹^ORCID

Affiliation:

1. Laboratory for Pathogenesis of Clinical Drug Resistance and Persistence, San Diego State University, San Diego, California, USA

2. Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

Abstract

Mycobacterium tuberculosis , the primary causative agent of tuberculosis, kills more humans than any other infectious bacterium. Yet 40% of its genome is functionally uncharacterized, leaving much about the genetic basis of its resistance to antibiotics, capacity to withstand host immunity, and basic metabolism yet undiscovered.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Science Foundation

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00673-21

Reference132 articles.

1. On expert curation and scalability: UniProtKB/Swiss-Prot as a case study

2. BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS

3. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv

5. TB database: an integrated platform for tuberculosis research

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Using a whole genome co‐expression network to inform the functional characterisation of predicted genomic elements from Mycobacterium tuberculosis transcriptomic data;Molecular Microbiology;2023-03-27

2. Hybran: Hybrid Reference Transfer and ab initio Prokaryotic Genome Annotation;2022-11-10

3. Genome-Wide Study of Drug Resistant Mycobacterium tuberculosis and Its Intra-Host Evolution during Treatment;Microorganisms;2022-07-17

4. Distribution of Common and Rare Genetic Markers of Second-Line-Injectable-Drug Resistance in Mycobacterium tuberculosis Revealed by a Genome-Wide Association Study;Antimicrobial Agents and Chemotherapy;2022-06-21

5. Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis;mBio;2022-02-22