Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Thiede Joshua M.¹,Dillon Nicholas A.¹^ORCID,Howe Michael D.¹,Aflakpui Ranee²,Modlin Samuel J.³^ORCID,Hoffner Sven E.³⁴,Valafar Faramarz³^ORCID,Minato Yusuke¹⁵,Baughn Anthony D.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

2. West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana

3. Laboratory for Pathogenesis of Clinical Drug Resistance and Persistence, Biomedical Informatics Research Center, Division of Epidemiology, School of Public Health, San Diego State University, San Diego, California, USA

4. Department of Global Public Health, Karolinska Institute, Stockholm, Sweden

5. Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Japan

Abstract

For decades, pyrazinamide has served as a cornerstone of tuberculosis therapy. Unlike any other antitubercular drug, pyrazinamide requires an acidic environment to exert its action.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00439-21

Reference73 articles.

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