E. coli Toxin YjjJ (HipH) Is a Ser/Thr Protein Kinase That Impacts Cell Division, Carbon Metabolism, and Ribosome Assembly

Author:

Gratani Fabio Lino1,Englert Till1,Nashier Payal1,Sass Peter2ORCID,Czech Laura3,Neumann Niels4,Doello Sofia4ORCID,Mann Petra5,Blobelt Rudolf1,Alberti Siegfried1,Forchhammer Karl4ORCID,Bange Gert35ORCID,Höfer Katharina5,Macek Boris1

Affiliation:

1. Quantitative Proteomics, Interfaculty Institute of Cell Biology, University of Tübingen, Tübingen, Germany

2. Microbial Bioactive Compounds, Interfaculty Institute for Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany

3. SYNMIKRO Research Center & Faculty of Chemistry, University of Marburg, Marburg, Germany

4. Organismic Interactions, Interfaculty Institute for Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany

5. Max Planck Institute for Terrestrial Microbiology, Marburg, Germany

Abstract

Adaptation to growth condition is the key for bacterial survival, and protein phosphorylation is one of the strategies adopted to transduce extracellular signal in physiological response. In a previous work, we identified YjjJ, a putative kinase, as target of the persistence-related HipA kinase.

Funder

Deutsche Forschungsgemeinschaft

Deutsches Forschungszentrum für Künstliche Intelligenz

EC | Horizon Europe | Excellent Science | HORIZON EUROPE Marie Sklodowska-Curie Actions

German-Israeli Foundation for Scientific Research and Development

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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