An Evolutionary Paradigm Favoring Cross Talk between Bacterial Two-Component Signaling Systems

Author:

Vemparala Bharadwaj1ORCID,Valiya Parambathu Arjun1ORCID,Saini Deepak Kumar23,Dixit Narendra M.12ORCID

Affiliation:

1. Department of Chemical Engineering, Indian Institute of Science, Bangalore, Karnataka, India

2. Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, Karnataka, India

3. Department of Molecular Reproduction, Development, and Genetics, Indian Institute of Science, Bangalore, Karnataka, India

Abstract

Bacteria use two-component signaling systems (TCSs) to sense and respond to environmental changes. The prevalent paradigm governing TCSs is specificity, where signal flow through TCSs is insulated; leakage to other TCSs is considered evolutionarily disadvantageous.

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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