PerSort Facilitates Characterization and Elimination of Persister Subpopulation in Mycobacteria-Reference-Cited by-同舟云学术

PerSort Facilitates Characterization and Elimination of Persister Subpopulation in Mycobacteria

Published:2020-12-22 Issue:6 Volume:5 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Srinivas Vivek¹,Arrieta-Ortiz Mario L.¹,Kaur Amardeep¹,Peterson Eliza J. R.¹^ORCID,Baliga Nitin S.¹²³⁴⁵^ORCID

Affiliation:

1. Institute for Systems Biology, Seattle, Washington, USA

2. Department of Biology, University of Washington, Seattle, Washington, USA

3. Department of Microbiology, University of Washington, Seattle, Washington, USA

4. Molecular Engineering Program, University of Washington, Seattle, Washington, USA

5. Lawrence Berkeley National Lab, Berkeley, California, USA

Abstract

Mycobacterium tuberculosis (MTB) persists and survives antibiotic treatments by generating phenotypically heterogeneous drug-tolerant subpopulations. The surviving cells, persisters, are a major barrier to the relapse-free treatment of tuberculosis (TB), which is already killing >1.8 million people every year and becoming deadlier with the emergence of multidrug-resistant strains.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Science Foundation

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.01127-20

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