Inactivation of Nitrite-Dependent Nitric Oxide Biosynthesis Is Responsible for Overlapped Antibiotic Resistance between Naturally and Artificially Evolved Pseudomonas aeruginosa

Author:

Kuang Su-fang1,Feng Ding-yun1,Chen Zhuang-gui1,Liang Zhuo-zheng1,Xiang Juan-juan1,Li Hui12ORCID,Peng Xuan-xian12,Zhang Tiantuo1

Affiliation:

1. The Third Affiliated Hospital and State Key Laboratory of Bio-Control, School of Life Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou, People’s Republic of China

2. Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China

Abstract

Infections with Pseudomonas aeruginosa have become a real concern among hospital-acquired infections, especially in cystic fibrosis patients and immunocompromised individuals. Control of the pathogen is challenging due to antibiotic resistance.

Funder

Bureau of Science and Information Technology of Guangzhou Municipality | Guangzhou Science and Technology Program key projects

NSFC | International Cooperation and Exchange Programme

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Reference33 articles.

1. Antimicrobial Resistance in ESKAPE Pathogens

2. Centers for Disease Control and Prevention. 2019. Antibiotic resistant threats in the United States 2019. https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf.

3. ECDC publishes 2015 surveillance data on antimicrobial resistance and antimicrobial consumption in Europe

4. Exogenous Alanine and/or Glucose plus Kanamycin Kills Antibiotic-Resistant Bacteria

5.

Metabolic mechanism of ceftazidime resistance in Vibrio alginolyticus

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