Horizontal Gene Transfer Is the Main Driver of Antimicrobial Resistance in Broiler Chicks Infected with Salmonella enterica Serovar Heidelberg

Author:

Oladeinde Adelumola1ORCID,Abdo Zaid2ORCID,Press Maximilian O.3ORCID,Cook Kimberly4,Cox Nelson A.1,Zwirzitz Benjamin56,Woyda Reed2ORCID,Lakin Steven M.2ORCID,Thomas Jesse C.7ORCID,Looft Torey8,Cosby Douglas E.1ORCID,Hinton Arthur1,Guard Jean1ORCID,Line Eric1,Rothrock Michael J.1,Berrang Mark E.1,Herrington Kyler9,Zock Gregory10,Plumblee Lawrence Jodie1ORCID,Cudnik Denice1,House Sandra1,Ingram Kimberly1,Lariscy Leah1,Wagner Martin56,Aggrey Samuel E.10ORCID,Chai Lilong10ORCID,Ritz Casey10ORCID

Affiliation:

1. U.S. National Poultry Research Center, USDA-ARS, Athens, Georgia, USA

2. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA

3. Phase Genomics Inc., Seattle, Washington, USA

4. Office of National Programs, USDA-ARS, Beltsville, Maryland, USA

5. Institute of Food Safety, Food Technology and Veterinary Public Health, University of Veterinary Medicine, Vienna, Austria

6. Austrian Competence Centre for Feed and Food Quality, Safety, and Innovation FFoQSI GmbH, Tulln, Austria

7. Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

8. National Animal Disease Center, USDA-ARS, Ames, Iowa, USA

9. Medical College of Georgia, Augusta, Georgia, USA

10. Poultry Science Department, University of Georgia, Athens, Georgia, USA

Abstract

The reported increase in antibiotic-resistant bacteria in humans has resulted in a major shift away from antibiotic use in food animal production. This shift has been driven by the assumption that removing antibiotics will select for antibiotic susceptible bacterial taxa, which in turn will allow the currently available antibiotic arsenal to be more effective.

Funder

Colorado State University

U.S. Department of Agriculture

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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