Filamentous Bacteriophages and the Competitive Interaction between Pseudomonas aeruginosa Strains under Antibiotic Treatment: a Modeling Study-Reference-Cited by-同舟云学术

Filamentous Bacteriophages and the Competitive Interaction between Pseudomonas aeruginosa Strains under Antibiotic Treatment: a Modeling Study

Published:2021-06-29 Issue:3 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Pourtois Julie D.¹²^ORCID,Kratochvil Michael J.³⁴^ORCID,Chen Qingquan⁴,Haddock Naomi L.⁴,Burgener Elizabeth B.⁵,De Leo Giulio A.¹²,Bollyky Paul L.⁴

Affiliation:

1. Department of Biology, Stanford University, Stanford, California, USA

2. Hopkins Marine Station, Stanford University, Pacific Grove, California, USA

3. Department of Materials Science and Engineering, Stanford University, Stanford, California, USA

4. Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA

5. Center for Excellence in Pulmonary Biology, Department of Pediatrics, Stanford University, Stanford, California, USA

Abstract

Filamentous phages are a frontier in bacterial pathogenesis, but the impact of these phages on bacterial fitness is unclear. In particular, Pf phages produced by Pa promote antibiotic tolerance but are metabolically expensive to produce, suggesting that competing pressures may influence the prevalence of Pf+ versus Pf− strains of Pa in different settings.

Funder

Cystic Fibrosis Foundation

Dr. Ralph and Marian Falk Medical Research Trust

HHS | National Institutes of Health

SU | Stanford Bio-X

Stanford University

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00193-21

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