Differential Binding of Carbapenems with the AdeABC Efflux Pump and Modulation of the Expression of AdeB Linked to Novel Mutations within Two-Component System AdeRS in Carbapenem-Resistant Acinetobacter baumannii-Reference-Cited by-同舟云学术

Differential Binding of Carbapenems with the AdeABC Efflux Pump and Modulation of the Expression of AdeB Linked to Novel Mutations within Two-Component System AdeRS in Carbapenem-Resistant Acinetobacter baumannii

Published:2022-08-30 Issue:4 Volume:7 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Roy Subhasree¹,Junghare Vivek²,Dutta Shanta¹,Hazra Saugata²³^ORCID,Basu Sulagna¹^ORCID

Affiliation:

1. Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India

2. Department of Bioscience and Bioengineering, Indian Institute of Technology Roorkee (IITR), Roorkee, Uttarakhand, India

3. Centre for Nanotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee, Uttarakhand, India

Abstract

AdeABC is an important efflux pump in A. baumannii that plays a role in resistance toward different antibiotics including the “last resort” antibiotic, carbapenem. This pump is regulated by a two-component system, AdeRS.

Funder

Indian Council of Medical Research

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.00217-22

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