Connections between Exoproteome Heterogeneity and Virulence in the Oral Pathogen Aggregatibacter actinomycetemcomitans

Author:

Fu Yanyan1,Maaβ Sandra2ORCID,du Teil Espina Marines1,Wolters Anouk H. G.3,Gong Yanan4,de Jong Anne5,Raangs Erwin1,Buist Girbe1,Westra Johanna6,Becher Dörte2,van Dijl Jan Maarten1ORCID

Affiliation:

1. University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Groningen, the Netherlands

2. University of Greifswald, Institute of Microbiology, Department of Microbial Proteomics, Greifswald, Germany

3. Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

4. Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China

5. University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute, Department of Molecular Genetics, Groningen, the Netherlands

6. University of Groningen, University Medical Center Groningen, Department of Rheumatology and Clinical Immunology, Groningen, the Netherlands

Abstract

Periodontitis is one of the most common inflammatory diseases worldwide, causing high morbidity and decreasing the quality of life of millions of people. The bacterial pathogen Aggregatibacter actinomycetemcomitans is strongly associated with aggressive forms of periodontitis.

Funder

China Scholarship Council

Graduate School of Medical Sciences of the University of Groningen

Netherlands organisation for scientific research

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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