Antimalarial Activity of Human Group IIA Secreted Phospholipase A 2 in Relation to Enzymatic Hydrolysis of Oxidized Lipoproteins-Reference-Cited by-同舟云学术

Antimalarial Activity of Human Group IIA Secreted Phospholipase A 2 in Relation to Enzymatic Hydrolysis of Oxidized Lipoproteins

Published:2019-11 Issue:11 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Dacheux Mélanie¹,Sinou Véronique²,Payré Christine³,Jeammet Louise³,Parzy Daniel⁴,Grellier Philippe¹,Deregnaucourt Christiane¹,Lambeau Gérard³

Affiliation:

1. Unité Molécules de Communication et Adaptation des Microorganismes (MCAM), Muséum National d’Histoire Naturelle, CNRS, Paris, France

2. UMR_MD1, Inserm U-1261, Faculté de Pharmacie, Université Aix-Marseille, Marseille, France

3. Université Côte d’Azur, CNRS, IPMC, Valbonne Sophia Antipolis, France

4. K-Plan, Département de Biologie, Marseille, France

Abstract

The level of human group IIA secreted phospholipase A 2 (hGIIA sPLA 2 ) is increased in the plasma of malaria patients, but its role is unknown. In parasite culture with normal plasma, hGIIA is inactive against Plasmodium falciparum , contrasting with hGIIF, hGV, and hGX sPLA 2 s, which readily hydrolyze plasma lipoproteins, release nonesterified fatty acids (NEFAs), and inhibit parasite growth.

Funder

ATM blanche

Fondation pour la Recherche Médicale

Agence Nationale de la Recherche

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00556-19

Reference100 articles.

1. Malaria: Biology and Disease