Ectopic Methylation of a Single Persistently Unmethylated CpG in the Promoter of the Vitellogenin Gene Abolishes Its Inducibility by Estrogen through Attenuation of Upstream Stimulating Factor Binding-Reference-Cited by-同舟云学术

Ectopic Methylation of a Single Persistently Unmethylated CpG in the Promoter of the Vitellogenin Gene Abolishes Its Inducibility by Estrogen through Attenuation of Upstream Stimulating Factor Binding

Published:2019-12 Issue:23 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Kallenberger Lia¹²³,Erb Rachel¹²³,Kralickova Lucie³,Patrignani Andrea⁴,Stöckli Esther²,Jiricny Josef¹²³^ORCID

Affiliation:

1. Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland

2. Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

3. Institute of Biochemistry, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland

4. Functional Genomics Center of the University of Zurich and the ETH Zurich, Zurich, Switzerland

Abstract

The enhancer/promoter of the vitellogenin II gene ( VTG ) has been extensively studied as a model system of vertebrate transcriptional control. While deletion mutagenesis and in vivo footprinting identified the transcription factor (TF) binding sites governing its tissue specificity, DNase hypersensitivity and DNA methylation studies revealed the epigenetic changes accompanying its hormone-dependent activation.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00436-19

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