Computational Analysis Identifies Human Adenovirus Type 55 as a Re-Emergent Acute Respiratory Disease Pathogen

Author:

Walsh Michael P.1,Seto Jason1,Jones Morris S.2,Chodosh James3,Xu Wenbo4,Seto Donald1

Affiliation:

1. Department of Bioinformatics and Computational Biology, George Mason University, 10900 University Blvd., MSN 5B3, Manassas, Virginia 20110

2. Clinical Investigation Facility, David Grant USAF Medical Center, Travis, California 94535

3. Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114

4. State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Nanwei Road 27, Xuanwu District, Beijing 100050, People's Republic of China

Abstract

ABSTRACT Novel human adenoviruses (HAdVs) arise from genome recombination. Analysis of HAdV type 55 from an outbreak in China shows a hexon recombination between HAdV-B11 and HAdV-B14, resulting in a genome that is 97.4% HAdV-B14. Sporadic appearances as a re-emergent pathogen and misidentification as “HAdV-B11a” are due to this partial hexon.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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