A Mutant of Mycobacterium smegmatis Defective in Dipeptide Transport-Reference-Cited by-同舟云学术

A Mutant of Mycobacterium smegmatis Defective in Dipeptide Transport

Published:1998-12-15 Issue:24 Volume:180 Page:6773-6775
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Bhatt Achal¹,Green Renee¹,Coles Roswell¹,Condon Michael²,Connell Nancy D.¹³

Affiliation:

1. Department of Microbiology and Molecular Genetics1 and

2. Department of Medicine, and Department of Surgery,3 UMDNJ/New Jersey Medical School, Newark, New Jersey 07103

3. National Tuberculosis Center,2

Abstract

ABSTRACT A mutant of Mycobacterium smegmatis unable to use the dipeptide carnosine (β-alanyl- l -histidine) as a sole carbon or nitrogen source was isolated. Carnosinase activity and the ability to grow on β-Ala and/or l -His were similar in the mutant and the wild type. However, the mutant showed significant impairment in the uptake of carnosine. This study is the first description of a peptide utilization mutant of a mycobacterium.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.180.24.6773-6775.1998

Reference19 articles.

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4. Genetic basis of histidine degradation in Bacillus subtilis;Kimhi Y.;J. Biol. Chem.,1970

5. Salmonella typhimurium peptidase active on carnosine;Kirsch M.;J. Bacteriol.,1978

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