Affiliation:
1. Department of Medical Microbiology, University of Edinburgh, Edinburgh, United Kingdom
Abstract
ABSTRACT
The Tn
1546
-related elements of 48 Van glycopetide-resistant enterococci were compared. Ten distinct Tn
1546
types were identified with variation primarily due to IS
1542
and IS
1216V
-like insertions. Clonal isolates frequently differed in their Tn
1546
type, indicating instability of Tn
1546
-related elements. A putative hybrid promoter was identified, generated upstream of
vanR
by the insertion of IS
1542
. The presence of this hybrid promoter was associated with constitutive expression of the
van
genes and elevated teicoplanin resistance.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
19 articles.
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