Affiliation:
1. Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom
Abstract
ABSTRACT
A Tn
1546
-related element with IS
1216V
at position 8839 underwent a structural change after storage of the host strain of
Enterococcus faecium
at 4°C. The element acquired IS
1542
at position 3932, nucleotides 8732 to 8831 were deleted, and the first 3417 nucleotides were lost and replaced by an inverted copy of the IS
1216V–vanY–vanZ
-inverted-repeat block from the 3′ end. Insertion sequence movement is likely to play a key role in the evolution of VanA resistance elements.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
30 articles.
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