Fosamprenavir with Ritonavir Pharmacokinetics during Pregnancy

Author:

Eke Ahizechukwu C.12ORCID,Wang Jiajia3,Amin Khadija4,Shapiro David E.3,Stek Alice5,Smith Elizabeth6,Chakhtoura Nahida7,Basar Michael8,George Kathleen9,Knapp Katherine M.10,João Esaú C.11,Rungruengthanakit Kittipong12,Capparelli Edmund413,Burchett Sandra14,Mirochnick Mark15,Best Brookie M.413,

Affiliation:

1. Division of Maternal Fetal Medicine and Clinical Pharmacology, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. Doctoral Training Program (PhD), Graduate Training Program in Clinical Investigation, Johns Hopkins University School of Public Health, Baltimore, Maryland, USA

3. Center for Biostatistics in AIDS Research, Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

4. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA

5. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Southern California School of Medicine, Los Angeles, California, USA

6. Pediatric Medicine Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA

7. Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA

8. Frontier Science and Technology Research Foundation, Amherst, New York, USA

9. Family Health International, Durham, North Carolina, USA

10. Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

11. Infectious Diseases Department, Hospital dos Servidores do Estado, Rio de Janeiro, Brazil

12. Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand

13. Pediatrics Department-Rady Children’s Hospital, University of California, San Diego, San Diego, California, USA

14. Division of Infectious Diseases, Department of Pediatrics, Children’s Hospital Boston, Boston, Massachusetts, USA

15. Division of Neonatology, Department of Pediatrics, Boston University School of Medicine, Boston, Massachusetts, USA

Abstract

The purpose of this study was to evaluate the pharmacokinetics of ritonavir-boosted fosamprenavir during pregnancy and postpartum. Amprenavir (the active moiety of fosamprenavir) and ritonavir intensive pharmacokinetic evaluations were performed at steady state during the second and third trimesters of pregnancy and postpartum. Plasma concentrations of amprenavir and ritonavir were measured using high-performance liquid chromatography. The target amprenavir area under the concentration-versus-time curve (AUC) was higher than the 10th percentile (27.

Funder

HHS | National Institutes of Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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