A Widely Conserved Gene Cluster Required for Lactate Utilization in Bacillus subtilis and Its Involvement in Biofilm Formation-Reference-Cited by-同舟云学术

A Widely Conserved Gene Cluster Required for Lactate Utilization in Bacillus subtilis and Its Involvement in Biofilm Formation

Published:2009-04-15 Issue:8 Volume:191 Page:2423-2430
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Chai Yunrong¹,Kolter Roberto²,Losick Richard¹

Affiliation:

1. Department of Molecular and Cellular Biology, the Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138

2. Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115

Abstract

ABSTRACT We report that catabolism of l -lactate in Bacillus subtilis depends on the previously uncharacterized yvfV-yvfW-yvbY (herein renamed lutABC ) operon, which is inferred to encode three iron-sulfur-containing proteins. The operon is under the dual control of a GntR-type repressor (LutR, formerly YvfI) and the master regulator for biofilm formation SinR and is induced during growth in response to l -lactate. Operons with high similarity to lutABC are present in the genomes of a variety of gram-positive and gram-negative bacteria, raising the possibility that LutABC is a widely conserved and previously unrecognized pathway for the utilization of l -lactate or related metabolites.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.01464-08

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