Longitudinal Evolution of the Pseudomonas-Derived Cephalosporinase (PDC) Structure and Activity in a Cystic Fibrosis Patient Treated with β-Lactams-Reference-Cited by-同舟云学术

Longitudinal Evolution of the Pseudomonas-Derived Cephalosporinase (PDC) Structure and Activity in a Cystic Fibrosis Patient Treated with β-Lactams

Published:2022-10-26 Issue:5 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Colque Claudia A.¹²^ORCID,albarracín Orio Andrea G.¹²³^ORCID,Tomatis Pablo E.⁴⁵^ORCID,Dotta Gina⁴,Moreno Diego M.⁵⁶^ORCID,Hedemann Laura G.¹²,Hickman Rachel A.⁷⁸,Sommer Lea M.⁷⁸^ORCID,Feliziani Sofía¹²,Moyano Alejandro J.¹²^ORCID,Bonomo Robert A.⁹¹⁰^ORCID,K. Johansen Helle⁷⁸¹¹^ORCID,Molin Søren⁸^ORCID,Vila Alejandro J.⁴⁵^ORCID,Smania Andrea M.¹²^ORCID

Affiliation:

1. Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Biológica Ranwel Caputto, Córdoba, Argentina

2. CONICET, Universidad Nacional de Córdoba, Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), Córdoba, Argentina

3. IRNASUS, Universidad Católica de Córdoba, CONICET, Facultad de Ciencias Agropecuarias, Córdoba, Argentina

4. Instituto de Biología Molecular y Celular de Rosario (IBR), CONICET, Universidad Nacional de Rosario, Rosario, Argentina

5. Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina

6. IQUIR, Instituto de Química de Rosario, CONICET, Universidad Nacional de Rosario, Rosario, Argentina

7. Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark

8. Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Lyngby, Denmark

9. Departments of Molecular Biology and Microbiology, Medicine, Biochemistry, Pharmacology, and Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USA

10. Senior Clinical Scientist Investigator, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA

11. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

Abstract

Antibiotics are becoming increasingly ineffective to treat bacterial infections. It has been consequently predicted that infectious diseases will become the biggest challenge to human health in the near future. Pseudomonas aeruginosa is considered a paradigm in antimicrobial resistance as it exploits intrinsic and acquired resistance mechanisms to resist virtually all antibiotics known.

Funder

MINCyT | Agencia Nacional de Promoción Científica y Tecnológica

Ministerio de Ciencia y Tecnología, Gobierno de la Provincia de Córdoba

UNC | Secretaria de Ciencia y Tecnología - Universidad Nacional de Córdoba

HHS | National Institutes of Health

Novo Nordisk

Rigshospitalet

Lundbeckfonden

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject