Metabolite Damage and Damage Control in a Minimal Genome

Author:

Haas Drago1,Thamm Antje M.2,Sun Jiayi2,Huang Lili3,Sun Lijie4,Beaudoin Guillaume A. W.2,Wise Kim S.4,Lerma-Ortiz Claudia2,Bruner Steven D.5,Breuer Marian6,Luthey-Schulten Zaida7,Lin Jiusheng89,Wilson Mark A.89,Brown Greg1011,Yakunin Alexander F.10,Kurilyak Inna12,Folz Jacob12,Fiehn Oliver12,Glass John I.4,Hanson Andrew D.2,Henry Christopher S.1314,de Crécy-Lagard Valérie115

Affiliation:

1. Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA

2. Horticultural Sciences Department, University of Florida, Gainesville, Florida, USA

3. Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, USA

4. J. Craig Venter Institute, La Jolla, California, USA

5. Chemistry Department, University of Florida, Gainesville, Florida, USA

6. Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands

7. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

8. Department of Biochemistry, University of Nebraska, Lincoln, Nebraska, USA

9. Redox Biology Center, University of Nebraska, Lincoln, Nebraska, USA

10. Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Canada

11. Centre for Environmental Biotechnology, School of Natural Sciences, Bangor University, Bangor, United Kingdom

12. West Coast Metabolomics Center, UC Davis, Davis, California, USA

13. Data Science and Learning, Argonne National Laboratory, Argonne, Illinois, USA

14. Consortium for Advanced Science and Engineering, The University of Chicago, Chicago, Illinois, USA

15. University of Florida Genetics Institute, Gainesville, Florida, USA

Abstract

Metabolite damage and repair mechanisms are being increasingly recognized. We present here compelling genetic and biochemical evidence for the universal importance of these mechanisms by demonstrating that stripping a genome down to its barest essentials leaves metabolite damage control systems in place.

Funder

National Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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