Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity

Author:

Ries Laure Nicolas Annick1,Alves de Castro Patricia2,Pereira Silva Lilian2,Valero Clara2,dos Reis Thaila Fernanda2,Saborano Raquel3,Duarte Iola F.4,Persinoti Gabriela Felix5,Steenwyk Jacob L.6ORCID,Rokas Antonis6ORCID,Almeida Fausto1ORCID,Costa Jonas Henrique7ORCID,Fill Taicia7,Sze Wah Wong Sarah8,Aimanianda Vishukumar8ORCID,Rodrigues Fernando José Santos910,Gonçales Relber A.910,Duarte-Oliveira Cláudio910,Carvalho Agostinho910,Goldman Gustavo H.2ORCID

Affiliation:

1. Faculdade de Medicina de Ribeirão Preto, Departamento de Bioquímica e Imunologia, Universidade de São Paulo, São Paulo, Brazil

2. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Departamento de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil

3. University of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, England

4. CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, Portugal

5. Brazilian Biorenewables National Laboratory (LNBR), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Sao Paulo, Brazil

6. Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA

7. Instituto de Química, Departamento de Química Orgânica, Universidade de Campinas, Campinas, São Paulo, Brazil

8. Molecular Mycology Unit, Institut Pasteur, CNRS, UMR2000, Paris, France

9. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal

10. ICVS/3B’s - PT Government Associate Laboratory, Guimarães/Braga, Portugal

Abstract

Aspergillus fumigatus is an opportunistic fungal pathogen in humans. During infection, A. fumigatus is predicted to use host carbon sources, such as acetate, present in body fluids and peripheral tissues, to sustain growth and promote colonization and invasion.

Funder

Universidade do Minho, Portugal and Universidade do São Paulo, Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

UA | Centro de Investigação em Materiais Cerâmicos e Compósitos

MEC | Fundação para a Ciência e a Tecnologia

EC | European Regional Development Fund

"la Caixa" Foundation

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Howard Hughes Medical Institute

HHS | NIH | OSC | Common Fund

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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