A Novel Model for Papillomavirus-Mediated Anal Disease and Cancer Using the Mouse Papillomavirus-Reference-Cited by-同舟云学术

A Novel Model for Papillomavirus-Mediated Anal Disease and Cancer Using the Mouse Papillomavirus

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Blaine-Sauer Simon¹,Shin Myeong-Kyun¹,Matkowskyj Kristina A.²³⁴,Ward-Shaw Ella¹,Lambert Paul F.¹³

Affiliation:

1. McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

2. Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

3. University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA

4. William S. Middleton VA Medical Center, Madison, Wisconsin, USA

Abstract

We show, for the first time, that MmuPV1 infection is sufficient to efficiently mediate high-grade squamous intraepithelial lesions in the anal tract of mice using the NSG immunocompromised strain and that MmuPV1, in combination with the chemical carcinogen DMBA, has carcinogenic potential. We further show that MmuPV1 is able to persist for up to 6 months in the anal tract of FVB/NJ mice irradiated with UVB and contributes to high-grade disease and cancer in an immunocompetent strain.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01611-21

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