Passage of Treponema pallidum Through Membrane Filters of Various Pore Sizes

Author:

Chandler Francis W.1,Clark John W.1

Affiliation:

1. Venereal Disease Research Laboratory, National Communicable Disease Center, Public Health Service, Atlanta, Georgia 30333

Abstract

The passage of Treponema pallidum through commercially available Millipore membrane filters of various pore sizes was examined. No microscopically detectable organisms passed through a filter with a pore diameter of 0.22 μm. As pore size was increased, progressively more organisms passed through. Motile organisms passed through filters to a greater extent than nonmotile ones; however, 22% of the motile and 50% of the nonmotile T. pallidum organisms did not pass through the largest pore diameter tested (14.0 μm). Filtration of T. pallidum suspensions through membrane filters may offer a way of separating the organisms from larger particles of debris which accompany their extraction from rabbit testicular syphilomas.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference6 articles.

1. Statistical approach to evaluating the method of Morgan and Vryonis for enumerating Treponema pallidum;Artley C. W.;Appl. Microbiol.,1969

2. The filtration of spirochetes through graded collodion membranes;Hindle E.;J. Pathol. Bacteriol.,1933

3. A method for quantitation of inocula in experimental syphilis;Morgan H. J.;Amer. J. Syph Gonor. Vener. Dis.,1938

4. Morphological and pathogenic variations in Treponema pallidum;Noguchi H.;J. Exp. Med.,1912

5. Staff Venereal Disease Research Laboratory. 1969. Manual of Tests for Syphilis. PHS Publication No. 411 (revised January 1969). U.S. Government Printing Office Washington D.C.

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