Diverse and Flexible Transmission of fosA3 Associated with Heterogeneous Multidrug Resistance Regions in Salmonella enterica Serovar Typhimurium and Indiana Isolates-Reference-Cited by-同舟云学术

Diverse and Flexible Transmission of fosA3 Associated with Heterogeneous Multidrug Resistance Regions in Salmonella enterica Serovar Typhimurium and Indiana Isolates

Published:2020-01-27 Issue:2 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Fang Liang-Xing¹²³,Jiang Qi¹²³,Deng Guo-Hui¹²³,He Bing¹²³,Sun Ruan-Yang¹²³,Zhang Jin-Fei¹²³,Cen Dao-Ji¹²³,Miao Yuan-Yuan¹²³,Wang Dong¹²³,Guo Wen-Ying¹²³,Sun Jian¹²³^ORCID,Liu Ya-Hong¹²³⁴,Liao Xiao-Ping¹²³

Affiliation:

1. National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China

2. Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

3. Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China

4. Jiangsu Co-Innovation Centre for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China

Abstract

We identified fosA3 at a rate of 2.6% in 310 Salmonella isolates from food animals in Guangdong province, China. The fosA3 gene was genetically linked to diverse antibiotic resistance genes (ARGs), including mcr-1 , bla CTX-M-14/55 , oqxAB , and rmtB . These gene combinations were embedded in heterogeneous fosA3 -containing multidrug resistance regions on the transferable ST3-IncHI2 and F33:A−:B− plasmids and the chromosome.

Funder

International Cooperation and Exchange of the National Natural Science Foundation of China

National Natural Science Fund of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02001-19

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