Dissemination of the Fosfomycin Resistance GenefosA3with CTX-M β-Lactamase Genes andrmtBCarried on IncFII Plasmids among Escherichia coli Isolates from Pets in China

Abstract

ABSTRACTThe presence and characterization of plasmid-mediated fosfomycin resistance determinants amongEscherichia coliisolates collected from pets in China between 2006 and 2010 were investigated. Twenty-nine isolates (9.0%) were positive forfosA3, and all of them were CTX-M producers. ThefosA3genes were flanked by IS26and were localized on F2:A−:B− plasmids or on very similar F33:A−:B− plasmids carrying bothblaCTX-M-65andrmtB. These findings indicate that thefosA3gene may be coselected by antimicrobials other than fosfomycin.