The Combined Expression of the Nonstructural Protein NS1 and the N-Terminal Half of NS2 (NS2 1-180 ) by ChAdOx1 and MVA Confers Protection against Clinical Disease in Sheep upon Bluetongue Virus Challenge-Reference-Cited by-同舟云学术

The Combined Expression of the Nonstructural Protein NS1 and the N-Terminal Half of NS2 (NS2 1-180 ) by ChAdOx1 and MVA Confers Protection against Clinical Disease in Sheep upon Bluetongue Virus Challenge

Published:2022-02-09 Issue:3 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Utrilla-Trigo Sergio¹,Jiménez-Cabello Luis¹,Calvo-Pinilla Eva¹,Marín-López Alejandro¹²,Lorenzo Gema¹,Sánchez-Cordón Pedro¹,Moreno Sandra¹,Benavides Julio³,Gilbert Sarah⁴,Nogales Aitor¹^ORCID,Ortego Javier¹^ORCID

Affiliation:

1. Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Valdeolmos, Spain

2. Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

3. Instituto de Ganadería de Montaña (CSIC-Universidad de León), León, Spain

4. The Jenner Institute, University of Oxford, Oxford, UK

Abstract

Current BTV vaccines are effective but they do not allow to distinguish between vaccinated and infected animals (DIVA strategy) and are serotype specific. In this work we have develop a DIVA multiserotype vaccination strategy based on adenoviral (ChAdOx1) and MVA vaccine vectors, the most widely used in current phase I and II clinical trials, and the conserved nonstructural BTV proteins NS1 and NS2. This immunization strategy solves the major drawbacks of the current marketed vaccines.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01614-21

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