7-Ketocholesterol Catabolism by Rhodococcus jostii RHA1-Reference-Cited by-同舟云学术

7-Ketocholesterol Catabolism by Rhodococcus jostii RHA1

Published:2010-01 Issue:1 Volume:76 Page:352-355
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Mathieu Jacques M.¹,Mohn William W.²,Eltis Lindsay D.²,LeBlanc Justin C.²,Stewart Gord R.²,Dresen Carola²,Okamoto Kenji³,Alvarez Pedro J. J.¹

Affiliation:

1. Department of Civil and Environmental Engineering, Rice University, Houston, Texas

2. Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada

3. Department of Biotechnology, Tottori University, Tottori, Japan

Abstract

ABSTRACT Oxysterols from steroid autooxidation have numerous harmful effects, but their biodegradation is poorly understood. Microarrays were used to study mineralization of the most common oxysterol, 7-ketocholesterol (7KC), by Rhodococcus jostii RHA1. Growth on 7KC versus growth on cholesterol resulted in 363 differentially expressed genes, including upregulation of two large gene clusters putatively encoding steroid catabolism. Despite this difference, 7KC degradation required key genes involved in cholesterol degradation, indicating a common catabolic route.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.02538-09

Reference20 articles.

1. Bach, D., R. F. Epand, R. M. Epand, and E. Wachtel. 2008. Interaction of 7-ketocholesterol with two major components of the inner leaflet of the plasma membrane: phosphatidylethanolamine and phosphatidylserine. Biochemistry47:3004-3012.

2. Bosco, D. A., D. M. Fowler, Q. Zhang, J. Nieva, E. T. Powers, P. Wentworth, Jr., R. A. Lerner, and J. W. Kelly. 2006. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nat. Chem. Biol.2:249-253.

3. Brown, A. J., and W. Jessup. 1999. Oxysterols and atherosclerosis. Atherosclerosis142:1-28.

4. Coleman, J. P., W. B. White, B. Egestad, J. Sjovall, and P. B. Hylemon. 1987. Biosynthesis of a novel bile acid nucleotide and mechanism of 7 alpha-dehydroxylation by an intestinal Eubacterium species. J. Biol. Chem.262:4701-4707.

5. Dawson, J. A., D. H. Mallonee, I. Bjorkhem, and P. B. Hylemon. 1996. Expression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli. J. Lipid Res.37:1258-1267.

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