Affiliation:
1. Institute of Pathology, Sai Ying Pun Polyclinic, Hong Kong.
Abstract
Of 5,667 strains of Neisseria gonorrhoeae isolated from the Government Social Hygiene (sexually transmitted disease) Clinics in Hong Kong from 1990 to 1992, there was a trend toward an increase in the percentage of strains resistant in vitro to 0.01 and 0.1 microgram of ofloxacin per ml, with 54.3 and 5.5% resistant strains, respectively, in January 1990, rising to 95.3 and 41.5%, respectively, in December 1992. The percentage of strains for which the MIC is > 1 microgram/ml remains stable, and no clinical failure has yet been seen. This trend of decreasing susceptibility warrants close monitoring when ofloxacin is used as first-line treatment for gonorrhea.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference17 articles.
1. Efficacy and safety of ofloxacin in the treatment of nongonococcal sexually transmitted disease;Batteiger B. E.;Am. J. Med.,1989
2. Multicenter randomized study of single-dose ofloxacin versus amoxicillin-probenecid for treatment of uncomplicated gonococcal infection;Black J. R.;Antimicrob. Agents Chemother.,1989
3. A prospective randomized trial of ofloxacin vs. doxycycline in the treatment of uncomplicated male urethritis;Boslego J. W.;Sex. Transm. Dis.,1988
4. Evaluation of ofloxacin in the treatment of mucopurulent cervicitis: response of chlamydia-positive and chlamydia-negative forms;Chandeying V.;J. Med. Assoc. Thailand,1989
5. Antibiotic susceptibility survey of Neisseria gonorrhoeae in Thailand;Clendennen T. E.;Antimicrob. Agents Chemother.,1992
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献