Localization of the WD Repeat-Containing Protein 5 to the Virion Assembly Compartment Facilitates Human Cytomegalovirus Assembly-Reference-Cited by-同舟云学术

Localization of the WD Repeat-Containing Protein 5 to the Virion Assembly Compartment Facilitates Human Cytomegalovirus Assembly

Published:2021-03-25 Issue:8 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Yang Bo¹²,Yao YongXuan¹²,Wu Hui³,Yang Hong²⁴,Ma Xue-Hui²⁴,Li Dong²⁴,Wang Xian-Zhang²⁴,Huang Sheng-Nan²⁴,Jiang Xuan¹²,Cheng Shuang²,Sun Jin-Yan²,Huang Zhen-Li⁵,Zhao CongJian⁶,McVoy Michael A.⁷,Ahn Jin-Hyun⁸^ORCID,Zeng Wen-Bo²,Britt William J.³,Gong Sitang¹,Luo Min-Hua¹²⁴⁹^ORCID

Affiliation:

1. Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China

2. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

3. Department of Pediatrics, University of Alabama School of Medicine, Birmingham, Alabama, USA

4. University of Chinese Academy of Sciences, Beijing, China

5. Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

6. Aier School of Ophthalmology, Aier Eye Institute, Central South University, Changsha, China

7. Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA

8. Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Suwon, Republic of Korea

9. Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

Abstract

Human cytomegalovirus (HCMV) has a large (∼235-kb) genome that contains over 170 open reading frames (ORFs) and exploits numerous cellular factors to facilitate its replication. In the late phase of HCMV infection, cytoplasmic membranes are reorganized to establish the virion assembly compartment (vAC), which has been shown to be necessary for efficient assembly of progeny virions.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02101-20

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