Congenital Human Cytomegalovirus Infection and the Enigma of Maternal Immunity-Reference-Cited by-同舟云学术

Congenital Human Cytomegalovirus Infection and the Enigma of Maternal Immunity

Published:2017-08 Issue:15 Volume:91 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Britt William J.¹

Affiliation:

1. Departments of Pediatrics, Microbiology, and Neurobiology, University of Alabama School of Medicine, Birmingham, Alabama, USA

Abstract

ABSTRACT Human cytomegalovirus (HCMV) is the most common viral infection acquired by the developing human fetus and can result in damage to the developing central nervous system. Although vaccine development to modify this congenital infection is ongoing, the unique epidemiology of maternal HCMV infections appears discordant with strategies for vaccine development. Several characteristics of congenital HCMV infections suggest that the efficacy of vaccines designed to induce responses similar to those that follow natural infection will be limited.

Funder

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02392-16

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