Fluconazole susceptibilities of Candida species and distribution of species recovered from blood cultures over a 5-year period

Author:

Price M F1,LaRocco M T1,Gentry L O1

Affiliation:

1. Infectious Disease Section, St. Luke's Episcopal Hospital, Houston, Texas 77030.

Abstract

The distribution and fluconazole susceptibilities of Candida species isolated over a 5-year period were investigated. Susceptibilities were determined by using a new microtiter procedure and the National Committee for Clinical Laboratory Standards (NCCLS) proposed standard. The new method correlated well with the NCCLS proposed standard and gave very clear end points. Results indicate that there are species-related differences in MICs as reflected in the MICs for 90% of species tested. Candida albicans is most susceptible to fluconazole, while Candida glabrata is among the least susceptible. These findings coincided with the observation of a shift in distribution of yeast species recovered from blood cultures from 1987 to 1992. C. albicans was the predominant species (87%) in the pre- or early fluconazole years but decreased to only 31% of the isolates in 1992. Thus, Candida species for which MICs of fluconazole were higher have become more prominent in recent years. Significantly, throughout this period, MICs for each species did not change appreciably.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference9 articles.

1. Fluconazole susceptibility testing of Candida albicans: microtiter method that is independent of inoculum size, temperature, and time of reading;Anaissie E.;Antimicrob. Agents Chemother.,1991

2. Growth phase in relation to ketoconazole and miconazole susceptibilities of Candida albicans;Beggs W. H.;Antimicrob. Agents Chemother.,1984

3. Galgiani J. 1989. Progress in standardizing antifungal susceptibility Total no. (%) positive cultures for:

4. C. albicans C. glabrata C. parapsilosis C. tropicalis 47 (87) 1 (2) 5 (9) 1 (2) 41 (75) 9 (15) 5 (8) 5 (8) 39 (85) 5 (11) 2 (4) 0 (0) 51 (46) 30 (27) 14 (13) 17 (15) 32 (31) 26 (26) 20 (20) 24 (24)

5. Recent developments in antifungal susceptibility testing;LaRocco M.;Clin. Microbiol. Newsl.,1991

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3