Adenovirus-Mediated Gene Expression In Vivo Is Enhanced by the Antiapoptotic Bcl-2 Gene-Reference-Cited by-同舟云学术

Adenovirus-Mediated Gene Expression In Vivo Is Enhanced by the Antiapoptotic Bcl-2 Gene

Published:1999-08 Issue:8 Volume:73 Page:6992-7000
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Bilbao Guadalupe¹,Contreras Juan L.²,Zhang Huang-Ge³,Pike M. Joyce⁴,Overturf Ken¹,Mikheeva Galina¹,Krasnykh Victor¹,Curiel David T.¹

Affiliation:

1. Gene Therapy Center,1

2. Transplant Center, Department of Surgery,2

3. Department of Medicine,3 and

4. Comprehensive Cancer Center,4 University of Alabama at Birmingham, Birmingham, Alabama 35294

Abstract

ABSTRACT An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.8.6992-7000.1999

Reference82 articles.

1. An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell death

2. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs;Albert M. L.;Nature,1998

3. Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains;Barr D.;Gene Ther.,1995

4. The CDK inhibitor p21WAF1/Cip1 is induced through a p300-dependent mechanism during NGF-mediated neuronal differentiation of PC12 cells;Billon N.;Oncogene,1996

5. Interleukin-2-activated natural killer cells can induce both apoptosis and necrosis in rat hepatocytes;Blom W. M.;Hepatology,1999

Cited by 20 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Construction and application of adenoviral vectors;Molecular Therapy - Nucleic Acids;2023-12

2. COVID-19: Myths and Reality;Biochemistry (Moscow);2021-07

3. COVID-19: мифы и реальность;Биохимия;2021-07-01

4. Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus Ad∆∆ through Bcl-2-dependent attenuation of autophagy;Oncogenesis;2018-01

5. IL-6 Protects against Hyperoxia-Induced Mitochondrial Damage via Bcl-2–Induced Bak Interactions with Mitofusions;American Journal of Respiratory Cell and Molecular Biology;2009-10