Humoral Immunity Reflects Altered T Helper Cell Bias in Borrelia burgdorferi -Infected γδ T-Cell-Deficient Mice-Reference-Cited by-同舟云学术

Humoral Immunity Reflects Altered T Helper Cell Bias in Borrelia burgdorferi -Infected γδ T-Cell-Deficient Mice

Published:2003-05 Issue:5 Volume:71 Page:2938-2940
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bockenstedt Linda K.¹,Shanafelt Marie-Claude¹,Belperron Alexia¹,Mao Jialing¹,Barthold Stephen W.²

Affiliation:

1. Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520

2. Center for Comparative Medicine, University of California, Davis, California 95616

Abstract

ABSTRACT In murine Lyme borreliosis, the absence of γδ T lymphocytes augments the T helper cell 2 type humoral response but does not alter disease susceptibility. Arthropod transmission of Borrelia burgdorferi spirochetes results in similar antibody isotypes when γδ T cells are present, suggesting that vector effects can negate γδ T-cell functions in vivo.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.71.5.2938-2940.2003

Reference29 articles.

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5. Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice

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