Structural Insight into Molecular Inhibitory Mechanism of InsP 6 on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp

Author:

Yang Yan1,Zhang Changhui1,Li Xuehui1,Li Li1,Chen Yanjuan1,Yang Xin2,Zhao Yao3,Chen Cheng4,Wang Wei2,Zhong Zhihui1,Yang Cheng1,Huang Zhen5,Su Dan16ORCID

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, People’s Republic of China

2. Institute of Life Sciences, Chongqing Medical University, Chongqing, People’s Republic of China

3. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China

4. School of Life Sciences, Tianjin University, Tianjin, People’s Republic of China

5. College of Life Sciences, Sichuan University, Chengdu, China

6. Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin, People’s Republic of China

Abstract

ASF is a highly contagious hemorrhagic viral disease in domestic pigs which causes high mortality. Currently, there are still no effective vaccines or specific drugs available against this particular virus.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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