COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions

Author:

Adeniji Opeyemi S.1,Giron Leila B.1,Purwar Mansi1,Zilberstein Netanel F.2,Kulkarni Abhijeet J.1,Shaikh Maliha W.2,Balk Robert A.2,Moy James N.2,Forsyth Christopher B.2,Liu Qin1,Dweep Harsh1,Kossenkov Andrew1,Weiner David B.1,Keshavarzian Ali2,Landay Alan2,Abdel-Mohsen Mohamed1ORCID

Affiliation:

1. The Wistar Institute, Philadelphia, Pennsylvania, USA

2. Rush University, Chicago, Illinois, USA

Abstract

A state of hyperinflammation and increased complement activation has been associated with coronavirus disease 2019 (COVID-19) severity. However, the pathophysiological mechanisms that contribute to this phenomenon remain mostly unknown.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute on Alcohol Abuse and Alcoholism

Foundation for AIDS Research

HHS | National Institutes of Health

HHS | NIH | National Institute of Neurological Disorders and Stroke

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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