IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition
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Published:2024-01-09
Issue:1
Volume:15
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Haslund-Gourley Benjamin S., Woloszczuk Kyra, Hou JintongORCID, Connors Jennifer, Cusimano Gina, Bell MathewORCID, Taramangalam Bhavani, Fourati Slim, Mege Nathan, Bernui Mariana, Altman Matthew C.ORCID, Krammer FlorianORCID, van Bakel HarmORCID, , , Ozonoff Al, Ehrlich Lauren I. R., Melamed Esther, Sesma Ana Fernandez, Simon Viviana, Pulendran Bali, Nadeau Kari C., Davis Mark M., McCoey Grace A., Sekaly Rafick, Baden Lindsey R., Levy Ofer, Schaenman Joanna, Reed Elaine F., Shaw Albert C., Hafler David A., Montgomery Ruth R., Kleinstein Steven H., Becker Patrice M., Augustine Alison D., Calfee Carolyn S., Erle David J., DeBakey Michael E., Corry David B., Kheradmand Farrah, Atkinson Mark A., Brakenridge Scott C., Higuita Nelson I. Agudelo, Metcalf Jordan P., Hough Catherine L., Messer William B., Kraft Monica, Bime Chris, Peters Bjoern, , Milliren Carly E., Syphurs Caitlin, McEnaney Kerry, Barton Brenda, Lentucci Claudia, Saluvan Mehmet, Chang Ana C., Hoch Annmarie, Albert Marisa, Shaheen Tanzia, Kho Alvin T., Liu Shanshan, Thomas Sanya, Chen Jing, Murphy Maimouna D., Cooney Mitchell, Hayati Arash Nemati, Bryant Robert, Abraham James, , Jayavelu Naresh Doni, Presnell Scott, Jancsyk Tomasz, Maguire Cole, Qi Jingjing, Lee Brian, Fourati Slim, Esserman Denise A., Guan Leying, Gygi Jeremy, Pawar Shrikant, Brito Anderson, Fragiadakis Gabriela K., Patel Ravi, Overton James A., Vita Randi, Westendorf Kerstin, Shannon Casey P., Tebbutt Scott J., , Thyagarajan Rama V., Rousseau Justin F., Wylie Dennis, Triplett Todd A., Kojic Erna, Chinthrajah Sharon, Ahuja Neera, Rogers Angela J., Artandi Maja, Geng Linda, Yendewa George, Powell Debra L., Kim James N., Simmons Brent, Goonewardene I. Michael, Smith Cecilia M., Martens Mark, Sherman Amy C., Walsh Stephen R., Issa Nicolas C., Salehi-Rad Ramin, Dela Cruz Charles, Farhadian Shelli, Iwasaki Akiko, Ko Albert I., Anderson Evan J., Mehta Aneesh K., Sevransky Jonathan E., Seyfert-Margolis Vicki, Leligdowicz Aleksandra, Matthay Michael A., Singer Jonathan P., Kangelaris Kirsten N., Hendrickson Carolyn M., Krummel Matthew F., Langelier Charles R., Woodruff Prescott G., Corry David B., Kheradmand Farrah, Anderson Matthew L., Guirgis Faheem W., Drevets Douglas A., Brown Brent R., Siegel Sarah A. R., Lu Zhengchun, Mosier Jarrod, Kimura Hiroki, , Khor Bernard, van Bakel Harm, Rahman Adeeb, Stadlbauer Daniel, Dutta Jayeeta, Xie Hui, Kim-Schulze Seunghee, Gonzalez-Reiche Ana Silvia, van de Guchte Adriana, Carreño Juan Manuel, Singh Gagandeep, Raskin Ariel, Tcheou Johnstone, Bielak Dominika, Kawabata Hisaaki, Kelly Geoffrey, Patel Manishkumar, Nie Kai, Yellin Temima, Fried Miriam, Sullivan Leeba, Morris Sara, Sieg Scott, Steen Hanno, van Zalm Patrick, Fatou Benoit, Mendez Kevin, Lasky-Su Jessica, Hutton Scott R., Michelotti Greg, Wong Kari, Jha Meenakshi, Viode Arthur, Kanarek Naama, Petrova Boryana, Zhao Yujiao, Bosinger Steven E., Boddapati Arun K., Tharp Greg K., Pellegrini Kathryn L., Beagle Elizabeth, Cowan David, Hamilton Sydney, Ribeiro Susan Pereira, Hodder Thomas, Rosen Lindsey B., Lee Serena, Wilson Michael R., Dandekar Ravi, Alvarenga Bonny, Rajan Jayant, Eckalbar Walter, Schroeder Andrew W., Tsitsiklis Alexandra, Mick Eran, Guerrero Yanedth Sanchez, Love Christina, Maliskova Lenka, Adkisson Michael, , Siles Nadia, Geltman Janelle, Hurley Kerin, Saksena Miti, Altman Deena, Srivastava Komal, Eaker Lily Q., Bermúdez-González Maria C., Beach Katherine F., Sominsky Levy A., Azad Arman R., Mulder Lubbertus C. F., Kleiner Giulio, Lee Alexandra S., Do Evan, Fernandes Andrea, Manohar Monali, Hagan Thomas, Blish Catherine A., Din Hena Naz, Roque Jonasel, Yang Samuel, Sigal Natalia, Chang Iris, Tribout Heather, Harris Paul, Consolo Mary, Edwards Carolyn, Lee Edward, Lin Edward, Croen Brett, Semenza Nicholas C., Rogowski Brandon, Melnyk Nataliya, Bell Mathew R., Furukawa Sara, McLin Renee, Schearer Pamela, Sheidy Julie, Tegos George P., Nagle Crystal, Smolen Kinga, Desjardins Michael, van Haren Simon, Mitre Xhoi, Cauley Jessica, Li Xiaofang, Tong Alexandra, Evans Bethany, Montesano Christina, Licona Jose Humberto, Krauss Jonathan, Chang Jun Bai Park, Izaguirre Natalie, Rooks Rebecca, Elashoff David, Brook Jenny, Ramires-Sanchez Estefania, Llamas Megan, Rivera Adreanne, Perdomo Claudia, Ward Dawn C., Magyar Clara E., Fulcher Jennifer A., Pickering Harry C., Sen Subha, Chaudhary Omkar, Coppi Andreas, Fournier John, Mohanty Subhasis, Muenker Catherine, Nelson Allison, Raddassi Khadir, Rainone Michael, Ruff William E., Salahuddin Syim, Schulz Wade L., Vijayakumar Pavithra, Wang Haowei, Wunder Elsio, Young H. Patrick, Rothman Jessica, Konstorum Anna, Chen Ernie, Cotsapas Chris, Grubaugh Nathan D., Wang Xiaomei, Xu Leqi, Asashima Hiromitsu, Bristow Laurel, Hussaini Laila, Hellmeister Kieffer, Samaha Hady, Wimalasena Sonia Tandon, Cheng Andrew, Spainhour Christine, Scherer Erin M., Johnson Brandi, Bechnak Amer, Ciric Caroline R., Hewitt Lauren, Carter Erin, Mcnair Nina, Panganiban Bernadine, Huerta Christopher, Usher Jacob, Vaysman Tatyana, Holland Steven M., Abe-Jones Yumiko, Asthana Saurabh, Beagle Alexander, Bhide Sharvari, Carrillo Sidney A., Chak Suzanna, Ghale Rajani, Gonzalez Ana, Jauregui Alejandra, Jones Norman, Lea Tasha, Lee Deanna, Lota Raphael, Milush Jeff, Nguyen Viet, Pierce Logan, Prasad Priya A., Rao Arjun, Samad Bushra, Shaw Cole, Sigman Austin, Sinha Pratik, Ward Alyssa, Willmore Andrew, Zhan Jenny, Rashid Sadeed, Rodriguez Nicklaus, Tang Kevin, Altamirano Luz Torres, Betancourt Legna, Curiel Cindy, Sutter Nicole, Paz Maria Tercero, Tietje-Ulrich Gayelan, Leroux Carolyn, Thakur Neeta, Vasquez Joshua J., Santhosh Lekshmi, Song Li-Zhen, Nelson Ebony, Moldawer Lyle L., Borresen Brittany, Roth-Manning Brittney, Ungaro Ricardo F., Oberhaus Jordan, Booth J. Leland, Sinko Lauren A., Brunton Amanda, Sullivan Peter E., Strnad Matthew, Lyski Zoe L., Coulter Felicity J., Micheleti Courtney, Conway Michelle, Francisco Dave, Molzahn Allyson, Erickson Heidi, Wilson Connie Cathleen, Schunk Ron, Sierra Bianca, Hughes Trina, Maecker Holden T.ORCID, Rouphael NadineORCID, Diray-Arce Joann, Wigdahl BrianORCID, Kutzler Michele A., Cairns Charles B.ORCID, Haddad Elias K.ORCID, Comunale Mary AnnORCID
Abstract
AbstractThe glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the role of IgM N-glycosylation has not been studied during human acute viral infection. The analysis of IgM N-glycosylation from healthy controls and hospitalized coronavirus disease 2019 (COVID-19) patients reveals increased high-mannose and sialylation that correlates with COVID-19 severity. These trends are confirmed within SARS-CoV-2-specific immunoglobulin N-glycan profiles. Moreover, the degree of total IgM mannosylation and sialylation correlate significantly with markers of disease severity. We link the changes of IgM N-glycosylation with the expression of Golgi glycosyltransferases. Lastly, we observe antigen-specific IgM antibody-dependent complement deposition is elevated in severe COVID-19 patients and modulated by exoglycosidase digestion. Taken together, this work links the IgM N-glycosylation with COVID-19 severity and highlights the need to understand IgM glycosylation and downstream immune function during human disease.
Funder
U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases
Publisher
Springer Science and Business Media LLC
Reference104 articles.
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