Affiliation:
1. Oral Bio-Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Special Administrative Region,1 and
2. College of Stomatology, West China University of Medical Sciences, Chengdu,2 People's Republic of China
Abstract
ABSTRACT
A total of 80
Candida
isolates representing 14 species were examined for their respective responses to an in vitro hemolytic test. A modification of a previously described plate assay system where the yeasts are incubated on glucose (3%)-enriched sheep blood agar in a carbon dioxide (5%)-rich environment for 48 h was used to evaluate the hemolytic activity. A group of eight
Candida
species which included
Candida albicans
(15 isolates),
C. dubliniensis
(2),
C. kefyr
(2),
C. krusei
(4),
C. zeylanoides
(1),
C. glabrata
(34),
C. tropicalis
(5), and
C. lusitaniae
(2) demonstrated both alpha and beta hemolysis at 48 h postinoculation. Only alpha hemolysis was detectable in four
Candida
species, viz.,
C. famata
(3),
C. guilliermondii
(4),
C. rugosa
(1), and
C. utilis
(1), while
C. parapsilosis
(5) and
C. pelliculosa
(1) failed to demonstrate any hemolytic activity after incubation for 48 h or longer. This is the first study to demonstrate the variable expression profiles of hemolysins by different
Candida
species.
Publisher
American Society for Microbiology
Cited by
208 articles.
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