CARB-9, a Carbenicillinase Encoded in the VCR Region of Vibrio cholerae Non-O1, Non-O139 Belongs to a Family of Cassette-Encoded β-Lactamases-Reference-Cited by-同舟云学术

CARB-9, a Carbenicillinase Encoded in the VCR Region of Vibrio cholerae Non-O1, Non-O139 Belongs to a Family of Cassette-Encoded β-Lactamases

Published:2004-10 Issue:10 Volume:48 Page:4042-4046
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Petroni Alejandro¹,Melano Roberto G.¹²,Saka Héctor A.¹,Garutti Alicia¹,Mange Laura¹,Pasterán Fernando¹,Rapoport Melina¹,Miranda Mariana¹,Faccone Diego¹,Rossi Alicia¹,Hoffman Paul S.²,Galas Marcelo F.¹

Affiliation:

1. Servicio Antimicrobianos, Dpto. Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS “Dr. Carlos G. Malbrán,” Buenos Aires, Argentina

2. Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada

Abstract

ABSTRACT The gene bla CARB-9 was located in the Vibrio cholerae super-integron, but in a different location relative to bla CARB-7 . CARB-9 (pI 5.2) conferred β-lactam MICs four to eight times lower than those conferred by CARB-7, differing at Ambler's positions V97I, L124F, and T228K. Comparison of the genetic environments of all reported bla CARB genes indicated that the CARB enzymes constitute a family of cassette-encoded β-lactamases.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.10.4042-4046.2004

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