Nucleotide Sequence of the bla RTG-2 (CARB-5) Gene and Phylogeny of a New Group of Carbenicillinases-Reference-Cited by-同舟云学术

Nucleotide Sequence of the bla RTG-2 (CARB-5) Gene and Phylogeny of a New Group of Carbenicillinases

Published:2000-04 Issue:4 Volume:44 Page:1070-1074
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Choury Daniele¹,Szajnert Marie-France²,Joly-Guillou Marie-Laure³,Azibi Kemal²,Delpech Marc¹,Paul Gérard⁴

Affiliation:

1. Laboratoire de Biologie Moléculaire des Cellules Eucaryotes,1

2. INSERM U129,2 and

3. UFR Xavier-Bichat, 75018 Paris,3 France

4. Laboratoire de Recherche en Microbiologie,4 UFR Cochin Port-Royal, 75014 Paris, and

Abstract

ABSTRACT We determined the nucleotide sequence of the bla gene for the Acinetobacter calcoaceticus β-lactamase previously described as CARB-5. Alignment of the deduced amino acid sequence with those of known β-lactamases revealed that CARB-5 possesses an RTG triad in box VII, as described for the Proteus mirabilis GN79 enzyme, instead of the RSG consensus characteristic of the other carbenicillinases. Phylogenetic studies showed that these RTG enzymes constitute a new, separate group, possibly ancestors of the carbenicillinase family.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.4.1070-1074.2000

Reference28 articles.

1. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.;Altschul S. F.;Nucleic Acids Res.,1997

2. The structure of β-lactamases.;Ambler R. P.;Philos. Trans. R. Soc. Lond. Biol.,1980

3. Nucleotide sequence of the PSE-4 carbenicillinase gene and correlations with the Staphylococcus aureus PC1 β-lactamase crystal structure.;Boissinot M.;J. Biol. Chem.,1990

4. A functional classification scheme for β-lactamases and its correlation with molecular structure.;Bush K.;Antimicrob. Agents Chemother.,1995

5. The phototrophic bacterium Rhodopseudomonas capsulata sp108 encodes an indigenous class A beta-lactamase.;Campbell J. I. A.;Biochem. J.,1989

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