Mapping of functional regions of Clostridium perfringens type A enterotoxin-Reference-Cited by-同舟云学术

Mapping of functional regions of Clostridium perfringens type A enterotoxin

Published:1992-05 Issue:5 Volume:60 Page:2110-2114
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Hanna P C¹,Wieckowski E U¹,Mietzner T A¹,McClane B A¹

Affiliation:

1. Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261-2072.

Abstract

Studies were conducted to allow construction of an initial map of the structure-versus-function relationship of the Clostridium perfringens type A enterotoxin (CPE). Removal of the N-terminal 25 amino acids of CPE increased the primary cytotoxic effect of CPE but did not affect binding. CPE sequences required for at least four epitopes were also identified.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.60.5.2110-2114.1992

Reference28 articles.

1. Collier R. J. 1990. Diphtheria toxin: structure and function of a cytocidal protein p. 3-19. In J. Moss and M. Vaughn (ed.) ADP-ribosylating toxins and G proteins: insights into signal transduction. American Society for Microbiology Washington D.C.

2. Inhibition of protein synthesis by a tryptic polypeptide of Clostridium perfringens type A enterotoxin;Granum P. E.;Biochim. Biophys. Acta,1982

3. Trypsin activation of enterotoxin from Clostridium perfringens type A;Granum P. E.;Biochim. Biophys. Acta,1981

4. A recombinant C-terminal toxin fragment provides evidence that membrane insertion is important for Clostridium perfringens enterotoxin cytotoxicity;Hanna P. C.;Mol. Microbiol.,1991

5. Localization of the receptor-binding region of Clostridium perfringens enterotoxin utilizing cloned toxin fragments and synthetic peptides. The 30 C-terminal amino acids define a functional binding region;Hanna P. C.;J. Biol. Chem.,1991

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