Safety of Attenuated Smallpox Vaccine LC16m8 in Immunodeficient Mice-Reference-Cited by-同舟云学术

Safety of Attenuated Smallpox Vaccine LC16m8 in Immunodeficient Mice

Published:2014-09 Issue:9 Volume:21 Page:1261-1266
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Yokote Hiroyuki¹,Shinmura Yasuhiko¹,Kanehara Tomomi¹,Maruno Shinichi¹,Kuranaga Masahiko¹,Matsui Hajime¹,Hashizume So²

Affiliation:

1. The Chemo-Sero-Therapeutic Research Institute (Kaketsuken), Okubo, Kita-ku Kumamoto-shi, Kumamoto, Japan

2. Chiba University, Yayoicho, Chiba-shi, Chiba, Japan

Abstract

ABSTRACT Freeze-dried live attenuated smallpox vaccine LC16m8 prepared in cell culture has been the sole smallpox vaccine licensed in Japan since 1975 and was recently recommended as a WHO stockpile vaccine. We evaluated the safety of recently remanufactured lots of LC16m8 using a series of immunodeficient mouse models. These models included suckling mice, severe combined immunodeficiency disease (SCID) mice, and wild-type mice treated with cyclosporine. LC16m8 showed extremely low virulence in each of the three mouse models compared with that of its parental strains, Lister and LC16mO. These results provide further evidence that LC16m8 is one of the safest replication-competent smallpox vaccines in the world and may be considered for use in immunodeficient patients.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00199-14

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