Evaluating the Contribution of the Predicted Toxin–Antitoxin System HigBA to Persistence, Biofilm Formation, and Virulence in Burkholderia pseudomallei-Reference-Cited by-同舟云学术

Evaluating the Contribution of the Predicted Toxin–Antitoxin System HigBA to Persistence, Biofilm Formation, and Virulence in Burkholderia pseudomallei

Published:2022-07-21 Issue:7 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Chapartegui-González Itziar¹^ORCID,Khakhum Nittaya¹,Stockton Jacob L.¹,Torres Alfredo G.¹²^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA

2. Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

Melioidosis is an underreported human disease caused by the Gram-negative intracellular pathogen Burkholderia pseudomallei ( Bpm ). Both the treatment and the clearance of the pathogen are challenging, with high relapse rates leading to latent infections.

Funder

HHS | National Institutes of Health

U.S. Department of Agriculture

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00035-22

Reference58 articles.

1. Melioidosis

2. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis

3. Melioidosis

4. Persister Cells

5. The role of metabolism in bacterial persistence

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