OPT-80 Eliminates Clostridium difficile and Is Sparing of Bacteroides Species during Treatment of C. difficile Infection-Reference-Cited by-同舟云学术

OPT-80 Eliminates Clostridium difficile and Is Sparing of Bacteroides Species during Treatment of C. difficile Infection

Published:2009-01 Issue:1 Volume:53 Page:261-263
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Louie Thomas J.¹,Emery Judy¹,Krulicki Walter¹,Byrne Brendan¹,Mah Manuel¹

Affiliation:

1. Division of Infectious Diseases, Departments of Medicine and Microbiology Infectious Diseases, University of Calgary, Calgary, Alberta, Canada, and Infection Prevention & Control Program, Calgary Health Region, Calgary, Alberta, Canada

Abstract

ABSTRACT During a 10-day treatment for Clostridium difficile infection, OPT-80 and vancomycin were comparably effective in reducing C. difficile counts. Bacteroides fragilis group counts appeared unaffected with increasing dosages of OPT-80, whereas vancomycin was markedly suppressive. Retention of components of the normal microflora might lower the risk of recurrent disease.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01443-07

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