Affiliation:
1. Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
Abstract
ABSTRACT
The enterobacterial
flhDC
master operon activates expression of the flagellar biogenesis gene hierarchy and also represses cell division. During
Proteus mirabilis
differentiation into elongated hyperflagellated swarm cells,
flhDC
transcription is strongly but transiently increased. We show that concentration of the FlhD and FlhC proteins is also tightly controlled at the posttranslational level. This is achieved by protein degradation, which is most severe after differentiation when the half-life of both proteins is ca. 2 min. Degradation is energy dependent and putatively involves the Lon protease.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
62 articles.
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