Vaccine Efficacy of a Lysine Auxotroph of Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Vaccine Efficacy of a Lysine Auxotroph of Mycobacterium tuberculosis

Published:2003-07 Issue:7 Volume:71 Page:4190-4192
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Pavelka Martin S.¹,Chen Bing²,Kelley Cynthia L.³,Collins Frank M.³,Jacobs William R.²

Affiliation:

1. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461

2. Howard Hughes Medical Institute

3. Laboratory of Mycobacterial Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892

Abstract

ABSTRACT The in vivo growth phenotype and vaccine efficacy of a lysine auxotrophic mutant of Mycobacterium tuberculosis strain H37Rv are described. An immunization experiment using a mouse model with an aerosol challenge showed that two doses of the M. tuberculosis mutant were required to generate protection equivalent to that of the Mycobacterium bovis BCG vaccine.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.71.7.4190-4192.2003

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