Affiliation:
1. Departments of Microbiology/Immunology
2. Medicine, Northwestern University, Chicago, Illinois 60611
Abstract
ABSTRACT
ExoU, a protein transported by the type III secretion system of
Pseudomonas aeruginosa
, is an important cytotoxin, though its mechanism of action is unclear. Here we show that the intracellular expression of ExoU is cytotoxic to
Saccharomyces cerevisiae
. Furthermore, internal amino- and carboxyl-terminal deletions confirmed that regions of ExoU previously shown to be essential for killing mammalian cells were also required for killing yeast cells. These findings indicate that
S. cerevisiae
is a useful model organism for the study of ExoU.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
51 articles.
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