Macrophages and Epithelial Cells Respond Differently to the Pseudomonas aeruginosa Type III Secretion System-Reference-Cited by-同舟云学术

Macrophages and Epithelial Cells Respond Differently to the Pseudomonas aeruginosa Type III Secretion System

Published:1999-06 Issue:6 Volume:67 Page:3151-3154
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Coburn Jenifer¹,Frank Dara W.²

Affiliation:

1. Division of Rheumatology and Immunology, Tufts-New England Medical Center, Boston, Massachusetts 02111,1 and

2. Department of Microbiology, Medical College of Wisconsin, Milwaukee, Wisconsin 532262

Abstract

ABSTRACT The multiple effects of Pseudomonas aeruginosa type III secretion have largely been attributed to variations in cytotoxin expression between strains. Here we show that the target cell type is also important. While lung epithelial cells showed significant changes in morphology but not viability when infected with P. aeruginosa , macrophages were efficiently killed by P. aeruginosa . Both responses were dependent on the type III secretion system.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.67.6.3151-3154.1999

Reference21 articles.

1. Exoenzyme S of Pseudomonas aeruginosa ADP-ribosylates the intermediate filament protein vimentin

2. Several GTP-binding proteins, including p21c-H-ras, are preferred substrates of Pseudomonas aeruginosa exoenzyme S;Coburn J.;J. Biol. Chem.,1989

3. ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury;Finck-Barbançon V.;Mol. Microbiol.,1997

4. Finck-Barbançon V. and D. W. Frank. Unpublished hybridization data.

5. Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S

Cited by 71 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Suppression of Pseudomonas aeruginosa type III secretion system by a novel calcium-responsive signaling pathway;iScience;2024-05

2. A compensatory RNase E variation increases Iron Piracy and Virulence in multidrug-resistant Pseudomonas aeruginosa during Macrophage infection;PLOS Pathogens;2023-04-07

3. A Compensatory RNase E Variation Increases Iron Piracy and Virulence in Multidrug-ResistantPseudomonas aeruginosaduring Macrophage Infection;2022-10-24

4. Potential Tamoxifen Repurposing to Combat Infections by Multidrug-Resistant Gram-Negative Bacilli;Pharmaceuticals;2021-05-26

5. Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa;PLOS Pathogens;2020-09-14