Trioxaquines and Heme-Artemisinin Adducts Inhibit the In Vitro Formation of Hemozoin Better than Chloroquine-Reference-Cited by-同舟云学术

Trioxaquines and Heme-Artemisinin Adducts Inhibit the In Vitro Formation of Hemozoin Better than Chloroquine

Published:2007-10 Issue:10 Volume:51 Page:3768-3770
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Loup Christophe¹,Lelièvre Joël¹²,Benoit-Vical Françoise¹²,Meunier Bernard³

Affiliation:

1. Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, 31077 Toulouse cedex 4, France

2. CHU Rangueil, Service de Parasitologie et Mycologie, 1 avenue Jean Poulhès, TSA 50032, 31059 Toulouse cedex 9, France

3. Palumed, rue Pierre et Marie Curie, BP 28262, 31682 Labège cedex, France

Abstract

ABSTRACT Trioxaquines, potential antimalarial agents, and heme-artemisinin adducts, resulting from the alkylation of heme by artemisinin, were evaluated as inhibitors of β-hematin formation in 10 M acetate medium at pH 5.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00239-07

Reference21 articles.

1. Trioxaquines Are New Antimalarial Agents Active on All Erythrocytic Forms, Including Gametocytes

2. Dechy-Cabaret, O., F. Benoit-Vical, C. Loup, A. Robert, H. Gornitzka, A. Bonhoure. H. Vial, J.-F. Magnaval, J.-P. Séguéla, and B. Meunier. 2004. Synthesis and antimalarial activity of trioxaquine derivatives. Chem. Eur. J.10:1625-1636.

3. Deharo, E., R. N. Garcia, P. Oporto, A. Gimenez, M. Sauvin, V. Jullian, and H. Ginsburg. 2002. A non-radiolabelled ferriprotoporphyrin IX biomineralisation inhibition test for the high throughput screening of antimalarial compounds. Exp. Parasitol.100:252-256.

4. Dorn, A., S. R. Vippagunta, H. Matile, A. Budendorf, J. L. Vennerstrom, and R. G. Ridley. 1998. A comparison and analysis of several ways to promote haematin (haem) polymerisation and an assessment of its initiation in vitro. Biochem. Pharmacol.55:737-747.

5. Egan, T. J. 2002. Physico-chemical aspects of hemozoin (malaria pigment) structure and formation. J. Inorg. Biochem.91:19-26.

Cited by 57 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Characterization of antimalarial activity of artemisinin-based hybrid drugs;Antimicrobial Agents and Chemotherapy;2024-07-09

2. Characterization of antimalarial activity of artemisinin-based hybrid drugs;2024-01-28

3. Chemogenomic Profiling of a Plasmodium falciparum Transposon Mutant Library Reveals Shared Effects of Dihydroartemisinin and Bortezomib on Lipid Metabolism and Exported Proteins;Microbiology Spectrum;2023-06-15

4. Therapeutical Utilization and Repurposing of Artemisinin and Its Derivatives: A Narrative Review;Advanced Biology;2023-05-13

5. Agglutination Reactions of Artemisinin-Type Drugs and Other Substances;BIO Web of Conferences;2023